Anyway, whatever the reason is, the outcome is the same - you cannot open the Outlook window because of this error: 'Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened.' There may be a few variations of this message depending on which Outlook version you use.
Happens sometimes in my environment when Skype for Business opens before Outlook. Causes some funkyness with Exchange. I'd recommend exiting Skype and Outlook, then opening Outlook first. I know it sounds dumb but it works here.
Edit: You might also want to check to see if you're running in Cached Exchange mode or not. Check if Outlook says 'Connected To: Microsoft Exchange' in the bottom right hand corner rather than 'Online With: Microsoft Exchange'. That's just another random thing that worked for us. If you’re in a situation where Microsoft Outlook and your Outlook Data Files are not opening, and we’re talking about the .pst and .ost files, then there’s an easy way to get things back to the way they were. Most folks will get an error message telling them they’re unable to open Outlook for whatever reasons.
The file cannot be opened message in Outlook
The first thing you want to do in such a case is to restart your computer and try again. Many times this has been known to help. If it does not, then you may want to start Outlook in Safe Mode and see.
Start Outlook in Safe Mode
OK, one of the reasons Outlook 2016 might fail to launch might have a lot to do with the extensions installed. To find out for sure, we’ll need to start the program in Safe Mode because, in that way, all extensions are disabled.
Starting Outlook in Safe Mode is quite easy. Just click the WinKey+R, type outlook /safe in the dialog box, then hit Enter. Should the software start in Safe Mode, then it has everything to do with the extensions or one of the extensions. You will need to disable the problematic extension.
Repair the Outlook data file
Microsoft has provided the Inbox Repair Tool which lets you recover folders and items from corrupted Personal Folders or .pst files. It can even recover items from an offline folder or .ost files. The OST Integrity Check Tool will help you fix corrupted .ost files.
To repair Outlook Inbox folder in Outlook 2016 close the software and cruise to the following location:
The next step, then, is to open SCANPST.EXE, then select the Outlook Data File you want to scan.
We should point out that with every scan, a new log file is created. However, it’s possible to open the Options area and turn off the automatic creation of a log file. If you want, you have the results attached to an already existing file.
Choose start to kick-start the scan. Now, should the scan come across errors, select Repair to begin the process of fixing them.
For those who weren’t aware, the scan creates a backup file while the repair process is running. Should there be a reason to change the default location and name of the backup file, just add a new name in the “Enter name of backup file” box, or browse and choose the name you prefer to use.
After the repair is complete, simply start Outlook 2016 with the Outlook Data File that was just repaired.
All the best!
TIP: Download this tool to quickly find & fix Windows errors automatically
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